Sir Isaac Newton vs Bill Nye is the forty-third installment of Epic Rap Battles of History and the tenth episode of Season 3. It features physicist and founder of the laws on gravity, Isaac Newton, rapping against the host of Bill Nye the Science Guy, Bill Nye, along with a surprise entry from astrophysicist, author, and science communicator, Neil deGrasse Tyson. It was released on June 16th, 2014.
However, Weird Al is the oldest actor to rap in an ERB.
In an AMA, the real Bill Nye said the following to the battle: "Love it. That's Weird Al himself Newtonising... and they're imitating me. I mean that's as immitationally flattering as it gets. I admit though, I'm not sure why I would be battling Isaac Newton rather than sitting down to share an apple and some peanut butter."
This makes him the eighth person confirmed to know about their battle.
In the podcast Control Guns Abortion, Peter confirms that Neil deGrasse Tyson had indeed seen his battle and had even offered to rap had they given him a call.
This makes him the ninth person confirmed to know about their battle.
This is the only battle during the second half of Season 3 where the rappers are announced in a different order from the title.
On February 28th, 2015, Weird Al posted a picture on Twitter of him and the real Bill Nye with a caption "It’s an Epic Rap Battles of History re-match!"
On August 22, 2016, Isaac Newton's quote, "If I have seen further than others, it is by standing upon the shoulders of giants.", was written in the description of the video.
This battle is featured on Medium Rarities, a bonus album included with the boxset Squeeze Box: The Complete Works of "Weird Al" Yankovic.